International Journal of Ayurveda and Pharma Research <div align="justify"> <p class="para1"><strong>International Journal of Ayurveda and Pharma Research (IJAPR)</strong>&nbsp;is an international peer reviewed Monthly open access Online and Print journal. The aim of the journal is to increase the impact of research in both academic and industry, with strong emphasis on quality and originality. The journal promotes to publish the articles in the field of&nbsp;<strong>Ayurveda, Siddha, Yoga, Naturopathy, Unani, Homeopathy and Allopathy</strong>&nbsp;systems of medicine and Pharmaceutical Sciences. Researchers may submit (1). Original Research Articles (2). Review articles (3). Book Reviews (4). Short Communications/ Research Letter (5). Case Report (6). Letter to the Editor/Correspondence.</p> </div> en-US (Dr B Srinivasulu M.D (Ayu.)) Fri, 10 Nov 2023 00:00:00 +0800 OJS 60 Pharmaceutico-Analytical and Antimicrobial Study of Amritank Rasa <p><em>Amritank Rasa</em> is a herbomineral formulation mentioned in the classical text of <em>Basavrajiyam </em>mainly used in the treatment of <em>Pancha Kasa</em>. This study aims to prepare the <em>Amritank Rasa</em> as per the classical text and conduct analytical and antimicrobial study of the prepared sample. The ingredients of <em>Amritank Rasa </em>are <em>Kajjali, Trikatu, Pippalimoola, Chavya, Chitraka, Vatsanabha </em>and <em>Saindhava lavana </em>all in equal parts and <em>bhavana </em>of <em>Bhringaraj swarasa. </em>The pharmaceutical procedure involves the preparation of<em> Amritank Rasa vati</em> in the 125mg dosage form. The pharmaceutical, analytical and antimicrobial parameters were compiled and data was recorded. The organoleptic parameters were, dark greyish in colour with pungent odour and taste, appearance was round and uncoated, and smooth in touch. The physiochemical parameters and quantitative parameters were, total ash was 5.5%, acid insoluble ash was 0.5% and loss on drying was 11.8%, average weight was 121mg, uniformity of weight test showed that all the tablets were not within the range of deviation from average weight, friability test was 0.51%, hardness was 5.3kg/cm<sup>2</sup> and disintegration time test showed that any tablet did not dissolve in 60 minutes. The sample was then subjected to advanced analytical parameters i.e., FTIR, PSD, XRF and XRD. The antimicrobial study of <em>Amritank rasa</em> showed that it is effective against S.aureus, E.coli, P.aeruginosa and C. albicans. The development of the present study will serve as reference standards for <em>Amritank Rasa</em> formulation, quality control and clinical research</p> Ritika Jaiswal, Deepak Raghuwanshi, Satyam Bhargava, Raj Kishore Pati Copyright (c) 2023 International Journal of Ayurveda and Pharma Research Fri, 10 Nov 2023 00:00:00 +0800 Preparation and Evaluation of Matruj SBA Hair Oil Containing Polyherbs for Arresting Hair Problems <p>Herbs are an essential component of the healthcare system in Ayurvedic medicine. In addition to being used in medicine, herbs are also utilized to make a variety of cosmetics and colours as well as to enhance one's appearance. The purpose of this research is to prepare polyherbal hair oil using plant-based ingredients which are fresh leaves of various plants. Polyherbal hair oil prepared by using multiple herbal components some of containing leaves, roots or whole plant. Firstly all raw materials are characterized by different parameters such as ash values, water and alcohol soluble extractives, TLCs, and phytochemical analysis, etc. Then prepared herbal oils were subjected to General characterization like sensitivity, Grittiness, sedimentation and Physical evaluation such as pH, acid value, viscosity, saponification value, specific gravity, density and stability study. The above parameters were found to be good and within standards. The characterization of all raw materials shows the different parameters and phytochemical analysis of phytoconstituents which are required for healing different hair problems. This is FDA approved herbal hair oil and it s already in use for a patients and it shows very good effect against all hair problems. Conclusively, combination of effective herbs could be used to improve hair growth, nourishes the scalp and prevents dandruff.</p> Vallabh Deshpande, Tanuja Deshpande Copyright (c) 2023 International Journal of Ayurveda and Pharma Research Fri, 10 Nov 2023 00:00:00 +0800 A Case Study on Ayurveda's Alleged Miracle Effect in Reducing CA 19-9 <p>A carbohydrate antigen called CA19-9 is used to identify pancreatic cancer patients. Pancreatic cancer patients and those with some other gastrointestinal carcinomas have been reported to have increased levels of CA19-9. Additionally, recent research suggests that this antigen plays an etiological function in pancreatitis and pancreatic cancer. Decreasing levels of the marker are indicative of a good prognosis and are commonly used to evaluate the effectiveness of therapies offered for pancreatic cancer.</p> <p>Lowering CA19-9 levels in patients with pancreatitis from the start of treatment has been demonstrated to be successful using Ayurvedic approaches. Research on this formulation as a preventive treatment for pancreatic cancer in people with pancreatitis may find fresh direction as a result of this observation. In this case report, the author and his team discuss Ayurvedic features of patient treatment through the use of Ayurvedic therapy. The pancreatitis patient with increased CA 19-9 levels who received treatment with Ayurvedic medicines is the subject of this report's observations.</p> Sunil Kumar Rai, Vaibhav Mishra, Pushpa Rai Copyright (c) 2023 International Journal of Ayurveda and Pharma Research Fri, 10 Nov 2023 00:00:00 +0800 Effect of Topical Application of Apamargadi Ghrita for Utsadana - Granulation Tissue Formation in Dushta Vranam <p>Non-healing ulcers are defined as spontaneous or traumatic lesions, mainly in lower extremities that persist despite appropriate treatment and do not proceed towards healing in a defined time period. Wound healing is a very dynamic and complex process. It is divided into 5 stages in which granulation tissue formation, angiogenesis and synthesis of collagen occurs in the proliferative phase. On the basis of clinical features, non-healing ulcers can be considered as <em>Dushtavrana</em> in Ayurveda. Different types of <em>Vrana</em> and sixty types of treatment modalities are well explained in Susrutha Samhitha. <em>Utsadana karma</em> is indicated in non-healing ulcers with poor granulation tissue. It is the procedure by which the deep floor of the wound is elevated using drugs which promote growth of new tissues. <em>Utsadana</em> of <em>Vrana</em> can be correlated with the proliferation of new tissues in the wound healing process. The conservative and surgical management for non-healing ulcers mainly includes debridement, skin grafting and wound dressings. Even though these treatment methods help in healing the ulcer, the rate of recurrence is more due to the formation of unhealthy granulation tissue. Also it leads to complications like infection, sensory deficits, scarring and bleeding. Susruthacharya mentioned the drugs for <em>Utsadana</em> in <em>Misrakadhyaya</em>, they are <em>Apamarga, Aswagandha, Suvarchala, Talapatri</em> and drugs of <em>Kakolyadi</em> <em>gana</em>. Dalhana in his commentary mentioned Ghrita preparation of these drugs for topical application. <em>Rasayana</em>, <em>Brimhana</em> and <em>Balya</em> properties of these drugs will help in the formation of healthy granulation tissue. In the present case study a 30yr old male patient visited the OPD with non healing ulcer was selected for <em>Utsadana karma</em>. Daily dressing was done with <em>Apamargadi ghrita</em>. The study was done for a period of 30 days The dimensions and attributes of the ulcer was systematically measured on 1<sup>st</sup>, 8<sup>th</sup>, 15<sup>th</sup>, 30<sup>th</sup> day and the result was assessed. The result shows that topical application of <em>Apamargadi ghrita</em> is effective in <em>Utsadana</em>- granulation tissue formation of <em>Dushta vrana</em>.</p> Athira Soman, P.Benedict, Sreelekha M.P Copyright (c) 2023 International Journal of Ayurveda and Pharma Research Fri, 10 Nov 2023 00:00:00 +0800 A Classical Review on Pharmaceutical and Analytical Study of Abhrak Bhasma <p><em>Abhrak bhasma</em> is an important traditional preparation which possesses higher therapeutic value and is widely prescribed for skin disorders, respiratory ailments and other chronic conditions. In order to ensure the quality of <em>Abhrak Bhasma</em>, needs a critical study of its pharmaceutical aspects such as quality of raw <em>Abhraka, Shodhan </em>process<em>, Dhanyabhrak</em> <em>Nirman</em> and <em>Maran</em> of <em>Abhraka </em>as well as <em>Abhrak Bhasma</em> tested on the basis of organoleptic characteristics and classical <em>Bhasma pariksha</em>. Hence the present study reviewed classical literature on <em>Abhrak Bhasma.</em><strong> Aim and Objectives:</strong> To review classical literature on Pharmaceutical study of <em>Abhrak Bhasma</em> with the objective to evaluate pharmaceutical aspects of <em>Abhrak Bhasma</em> critically on various factors such as <em>Shodhana</em> process, <em>Marana</em> process, temperature pattern, no. of <em>Putas</em> etc. <strong>Methods and Materials: </strong>All the classical literature in <em>Rasagrantha, Samgraha Grantha,</em> textbooks of Ayurveda and <em>Rasashastra</em> regarding pharmaceutical and analytical studies of <em>Abhrak Bhasma</em>. <strong>Observation and Result</strong>: The classical literature revealed that the pharmaceutical studies of <em>Abhrak Bhasma</em> like <em>Shodhana, Dhanyabhraka,</em> and <em>Marana</em> were done with specific guidelines in order to obtain the quality of <em>Bhasma</em>. Most of the literature followed <em>Triphala Kwatha</em> as a <em>Shodhana</em> media and <em>Kanji </em>for <em>Dhanyabhraka</em> process. The range of <em>Puta Pramana</em> observed was from 3 to 100 to ensure the quality of <em>Bhasma</em>. <em>Abhrak Bhasma</em> tested on the basis of organoleptic characteristics and classical <em>Bhasma pariksha</em>. <strong>Conclusion: </strong>In this review, the classical guidelines of pharmaceutical study of <em>Abhraka</em> <em>Shodhana, Dhanyabhraka,</em> and <em>Marana</em> were followed which set some important features in terms of temperature pattern, number of <em>Puta</em> etc. Further repeated studies on <em>Abhrak Bhasma</em> will help to establish standard operating procedure of it as well as fix its analytical parameters.</p> Mali Ramavtar, Dongre Sushma Copyright (c) 2023 International Journal of Ayurveda and Pharma Research Fri, 10 Nov 2023 00:00:00 +0800 Need of Standardization of Ayurveda Formulations <p>Standardization of herbal formulations is a process of setting some standard parameters which are essential for assuring the quality of the herbal formulations and it should be reproducible at any time of stability period of that formulations. Today many people all over the world experiencing the side effects of Modern medicine are shifting towards the traditional medical systems, among them most widely accepted is Ayurveda. Increased demand of herbal medicines, along with disparity in demand and supply of raw materials and profit mindedness of pharmaceutical agencies, has resulted substandard and unsafe products. The adulteration and substitution of drugs, methods of collection, storage and preservation of raw drugs, controversial opinions regarding formulations in classical text books, addition of preservatives and improper purification of toxic herbal and mineral drugs are the main problems that leading to the production of substandard and unsafe products. Authorities like WHO and Govt. of India has taken steps to standardize the individual drugs and formulations. Ministry of AYUSH have given the standard parameters for different types of preparations and few of the individual formulations are standardized in Ayurvedic pharmacopoeia of India. As the general population uses Ayurvedic medicines mainly as polyherbal formulations, standardization of each formulations is a need of hour for ensuring the quality medicines that leading to the global acceptance of Ayurveda.</p> Jyothi Raga P M, Vivek P, Harinarayanan C M Copyright (c) 2023 International Journal of Ayurveda and Pharma Research Fri, 10 Nov 2023 00:00:00 +0800 An Evaluation of Modern Medical Approaches and Ayurvedic Practices in Surgical and Parasurgical Interventions for Venereal Diseases in Men <p><em>Shalyatantra</em>, a significant section of Ayurveda, encompasses descriptions of surgical and para-surgical methods. Venereal diseases are illnesses often transmitted through sexual contact with an infected person, presenting a major global health concern, especially for pregnant women and newborns. Surgical and Para surgical interventions for venereal diseases in men are not widely known or discussed in Ayurveda. The scope and indications for these interventions are not well-explored. Common venereal diseases include chlamydial infection, gonorrhea, hepatitis, human papillomavirus, and genital herpes. If left untreated, chlamydia, a significant sexually transmitted bacterial infection, can lead to urethritis, which can be addressed through a surgical intervention known as perineal urethrostomy. Complications of gonorrhea, caused by the sexually transmitted bacterium Neisseria gonorrhoea, include phimosis, balanitis, and paraphimosis. These complications can be managed with surgical operations like the plastibell technique and circumcision. For <em>Charmakeelam</em>, parasurgical procedures such as <em>Agni karma</em> and <em>Kshara karma</em> are utilized for treatment. Genital herpes blisters can be surgically removed. In the case of <em>Upadamsam,</em> treatments like <em>Siravyadham</em> in <em>Medramadhyam</em> and <em>Jalookavacharanam</em> are listed as effective remedies for venereal disorders. Surgical procedures like <em>Chedhanam, Bedhanam, </em>and<em> Visravanam,</em> along with para-surgical techniques such as <em>Kshara Karma, Agni Karma, </em>and<em> Jalookavacharanam,</em> are described for various venereal diseases. In summary, both modern science and Ayurveda offer numerous surgical and para surgical methods to manage a wide range of ailments, including venereal diseases.</p> P.R Divya, G. Chandrakumar, N. Madhuri devi Copyright (c) 2023 International Journal of Ayurveda and Pharma Research Fri, 10 Nov 2023 00:00:00 +0800 A Systemic Review of Vegadharana on Cardiac Disorder <p><em>The term “Vega” means natural urge, and “Dharana” means suppression, so collectively, the word Vega Dharana means forceful suppression of natural urge. Vegas are naturally created in the body in order to maintain bodily equilibrium. Initiation of urges is a normal body activity through which unwanted and waste body products are expelled from the body. In order to facilitate the elimination of these substances, the body is equipped with Adharniya Vegas, which appears naturally. So it is very important to respond to these urges and not suppress them as and when they appear. In Ayurveda, it is broadly explained how </em>suppression of urges leads to serious illnesses<em>. The suppression of urges cause disturbance in homeostasis and lead to many metabolic disorders. Vega dharana as a Nidana is a unique concept of Ayurveda. Acharya Vagbhatta, </em>in the<em> Astang Hridaya Sutrasthana, </em>stated that the root cause of almost all diseases is<em> Vega udirandharane. </em>In Ayurveda<em>, Vegadharan </em>of<em> Adharniya vega </em>is one of the causative factors of<em> Hridaya roga. Today, cardiovascular disorders are the world’s leading cause of mortality and responsible for one out of every four deaths. The increased incidence of cardiovascular disease&nbsp;(CVD) </em>all over the world is due to faulty diet patterns and lifestyles<em>. </em>Approx eighty percent of premature deaths from CVD are preventable. The role of Ayurveda in the prevention and cure of cardiovascular disease is very systematic and good. It can be helpful in decreasing the incidence of cardiovascular disease.</p> Sushil Kumar Jha, Vivek Raghuwanshi, Santosh Kumar, Vijay Bahadur Singh Copyright (c) 2023 International Journal of Ayurveda and Pharma Research Fri, 10 Nov 2023 00:00:00 +0800 Interpretative Assessment of Smriti Mana and Buddhi in Ayurvedic Classical Texts <p>According to WHO estimations, India has 2443 disability-adjusted life years (DALYs) per 10,000 people who suffer from mental health issues. Also, the prevalence of age-related memory impairment was 3.6% in people 40 years of age and older, and 7.1% in people 65 years of age and older. In this world of gadgets, human beings are habitual in using devices for a lot of their work. Due to this, they are not in a habit of concentrating and memorizing things. Therefore, with time the human population keeps on losing their memory power. Many experts suggest that mentally challenging activities may help people with memory problems. Practicing yoga has also shown various health benefits, including improving memory and thus preventing memory impairment and related disorders. Numerous cognitive processes, including long-term memory, mental equilibrium, focus and concentration, attention span, processing speed, alternation ability, delayed and intermediate recall, executive function, verbal retention, and cognitive assessments are all improved by yoga.</p> Shilpa Shankarrao Walkikar, Sangeeta Mishra Copyright (c) 2023 International Journal of Ayurveda and Pharma Research Fri, 10 Nov 2023 00:00:00 +0800 Review of Swarasa Kalpana of Single Drug by Sharangadhara Samhita wsr to Phytochemical Analysis <p><em>Sharangadhara Samhita</em> is most important <em>Samhita</em> on <em>Bhaishajya Kalpana</em> (Ayurvedic pharmacy) and considered in <em>Laghutrayee</em>. It consists of three <em>Khand</em> (Division)- <em>Poorva Khand</em>, <em>Madhyam Khand</em>, <em>Uttar Khand</em>. <em>Ayurveda </em>offers personalised treatment according to each patient’s unique <em>Doshavastha</em>. <em>Acharya Charaka</em> has described <em>Chikitsa Chatushpada</em> which includes <em>Bhishak</em> (Physician), <em>Upasthata</em> (Medical Attendant), <em>Rogi</em> (Patient) and <em>Dravya</em> (medicine). The selection of <em>Dravya</em> (medicine) is important step in management of disease. <em>Acharya Charaka</em> has mentioned qualities of <em>Dravya</em> like 1) <em>Bahuta</em> 2) <em>Yogyatam</em> 3) <em>Aanekvidha kalpana</em> 4) <em>Sampat</em>. We use whole drug which contain many chemicals which are separated by <em>Agni</em> (Digestive system). These chemicals are absorbed and move in the body through <em>Rasavaha Strotasa. </em>&nbsp;They interact with each other and modify gene expression at cellular level. Proper <em>Kalpana </em>(formulations) facilitates better chemical separation, absorption and interaction. Thus, overall efficacy of the drug.</p> <p>Phytochemical analysis includes alkaloids, flavonoids, glycosides, phenols, saponins, sterols, tannins, anthraquinone etc. These are important phytochemicals and termed as active principles responsible for action of drug. Different <em>Bhaishajya Kalpana</em> are used to extract active principles of <em>Dravya</em> with the help of medium like water, oil, alcohol, <em>Ghrita</em>. <em>Panchavidha kashaya Kalpana</em> includes <em>Swarasa</em> (liquid), <em>Kalka</em> (paste), <em>Kwatha</em> (decoction), <em>Hima</em> (cold infusion) and <em>Phanta</em> (hot infusion) and are fundamental <em>Ayurvedic Bhaishajya Kalpana</em>. <em>Churna</em>, <em>Vati</em>, <em>Avaleha</em>, <em>Sneha</em> &amp; <em>Sandhan</em> <em>Kalpana</em> are modified forms of <em>Panchavidha</em> <em>Kashaya Kalpana</em>. Hence review of <em>Swarasa Kalpana </em>of single drug by <em>Sharangadhara Samhita</em> wsr to phytochemical analysis is taken.</p> Sumedha Suresh Kshirsagar, Amit Avalaskar Copyright (c) 2023 International Journal of Ayurveda and Pharma Research Fri, 10 Nov 2023 00:00:00 +0800 Ayurvedic Approach to Secondary Infertility <p>The God has blessed the female with most valuable gift of motherhood mother is also called as “<em>Janani''</em> who give birth to child. A woman hood is never considered complete without achievement of motherhood. Infertility is a burning issue because today's changing lifestyle and stress increases metabolic and hormonal disturbance as a result diabetes, PCOS, infertility. Our focus is, if a woman having normal anatomy of pelvic organ than she should conceive by natural way by Ayurvedic treatment because more side effect of ovulation induction and hormonal therapy. In Ayurveda <em>Bandhyatva</em> (infertility) mainly occurs vitiation of <em>Vata</em> and <em>Kapha</em> <em>Dosha</em>, in some case <em>Pitta</em> may involve. Fertility also depends on mental condition of couple as Charak says sound mind couple gets conceived easily. In this patient had also metabolic disturbance and stress, and ineffective endometrial receptiveness, so we choose <em>Ashwagandha</em> (<em>Withania somnifera</em>) as a anti-stress and normalize <em>Vata</em> and <em>Kapha</em> and <em>Shatavari</em> (<em>Asparagus racemosa</em>) for endometrial tonicity and <em>Sthanik</em> (endometrial) <em>Pitta Shaman</em> and <em>Chandraprabha</em> for <em>Apana Vata</em> (pelvic) disorder, balancing <em>Tridosha</em> and for <em>Dhatvagni</em> <em>Deepan</em> (better metabolism).</p> Priyanka Teva, Minal Khode, Alka Chouhan Copyright (c) 2023 International Journal of Ayurveda and Pharma Research Fri, 10 Nov 2023 00:00:00 +0800 Ayurvedic Management of Ovarian Cyst <p>Ovarian cyst is commonest problem facing by young women and foremost cause of infertility in women. Sedentary lifestyle, abnormal food habits, stressful life have influences on secretion of female hormones and thereby causing the manifestation of ovarian cyst. <strong>Methodology: </strong>In this present case study, 18 years old woman patient consulted to the OPD of <em>Kayachikitsa</em> of GAMCH, Bareilly with the complaints of pain in lower abdomen, irregular menses and generalized weakness. Ultrasonography was advised and finding suggestive of right ovarian cyst (37×33mm). She was given combination of traditional herbomineral Ayurvedic medicine for three months 20 days. <strong>Result: </strong>By the use of combination of traditional Ayurvedic medicines complete resolution of ovarian cyst was noticed in follow up- Ultrasonography. <strong>Discussion: </strong>This case study highlights on the management of ovarian cyst by Ayurvedic medicine.</p> Shreya Joshi, S.K Sahoo Copyright (c) 2023 International Journal of Ayurveda and Pharma Research Fri, 10 Nov 2023 00:00:00 +0800 A Clinical Study to Evaluate the Effect of Gomutra Arka Parisheka and Jathyadi Ghrita Application in Dushta Vrana w.s.r. to Non-Healing Ulcers <p><em>Vrana </em>is derived from the word <em>‘Vran’</em> which means one which causes destruction and discoloration of the body parts. Current estimates indicate nearly 6 million people suffer from chronic wound worldwide. Wounds can significantly interfere with quality of life of the patient. It can also complicate into gangrene, septicemia and death. <em>Sushruta Acharya</em> explains the features of <em>Dushta Vrana. Shashtir Upakrama </em>is mentioned as management for <em>Vrana.</em> <em>Gomutra</em> is one among the <em>Parisheka Upakrama Dravya</em> as well as in <em>Krimighna Upakrama Dravya</em>. <em>Jathyadi gritha</em> is prescribed as <em>Vrana ropaka.</em> An effort is made to evaluate the effect of <em>Gomutra</em> <em>Arka</em> <em>Parisheka</em> followed by <em>Jathyadi</em> <em>Ghrita</em> topical application in <em>Dushta Vrana</em>. It is a single group open labelled, randomized clinical study with pre test and post test design. 30 patients diagnosed with <em>Dushta vrana</em> fulfilling the inclusion criteria were selected for clinical trial with consent and subjected to <em>Gomutra Arka parisheka </em>with <em>Jatyadhi Ghrita</em> application followed by internal medications. The <em>Parisheka</em> and application was done for 7 days, data is recorded daily. Data obtained were recorded and statically analyzed. The treatment showed significant clinical improvement in controlling of pain, itching, foul smell and discharge. Clinical study showed good improvement in healing of ulcers in terms of clearing of slough, formation of granulation tissue and wound contraction.</p> B Prashanth, K Prashanth, H Ashwin Copyright (c) 2023 International Journal of Ayurveda and Pharma Research Fri, 10 Nov 2023 00:00:00 +0800 Preparation and Physico Chemical Analysis of Arka Lavan <p><em>Lavana kalpanas</em> are prepared by using predominantly <em>Lavanas</em> and herbs with <em>Putagni</em> <em>samskara</em>. <em>Arka lavana</em> is a herbo mineral preparation mentioned in Rasa Tarangini, Bhaishajya Ratnavali etc. It is indicated for <em>Yakrit Pleeha Rogas</em> along with water or butter milk as <em>Anupana</em>. The ingredients of this preparation are <em>Arka patra</em> (leaves of Calotropis procera) and <em>Saindhava lavana</em> (rock salt) in equal parts. Standardization is an essential part for proving therapeutic efficacy of a preparation. In this study <em>Arka lavana</em> has prepared according to the traditional method mentioned in textual reference from Rasa Tarangini ie; by <em>Puta Paka</em> method. The analytical study of this preparation was carried out including organoleptic and physicochemical parameters. The pharmaceutical procedure as well as Analytical results can be considered as a reference for further studies.</p> Sreekutty P.V, Shrinidhi R, Shubha P. U, Suchithra N. Prabhu, Chaithra S. Hebbar Copyright (c) 2023 International Journal of Ayurveda and Pharma Research Sat, 18 Nov 2023 16:41:52 +0800 Role of Agni in Panchakarma Practice: A Conceptual Study <p><em>Panchakarma</em> is a complex system of the expulsion of vitiated <em>Doshas</em> i.e., toxins, or waste and thus inducing purification of the body. They are therapeutic emesis (<em>Vamana</em>), therapeutic purgation (<em>Virechana</em>), decoction enema (<em>Niruha Vasti</em>), oil enema (<em>Anuvasana</em> <em>Vasti</em>), and instillation of medicine through the nose, (<em>Nasya</em>). All <em>Panchakarma</em> procedures are carried out in three stages known as <em>Poorvakarma</em> (pre-operative procedures), <em>Pradhanakarma</em> (operative procedures), and <em>Paschat karma</em> (post-operative procedures). <em>Agni</em> has a very important role in all these <em>Poorva-Pradhana</em> and <em>Paschat karma</em>. The order of <em>Panchakarma</em> starts with <em>Deepana-Pachana. </em>Then <em>Sneha-Sweda</em> and <em>Pradhana karma</em>. The role of <em>Deepana-Pachana</em> is the correction of deranged <em>Agni</em>. Because a <em>Dravya</em> has to get digested properly by the <em>Jatharagni</em> after which it starts its action, Exception for this in <em>Vamana dravya</em>. Furthermore, following <em>Pradhana karma</em>, the body experiences <em>Suddhi</em> as a result of the removal of <em>Doshas</em>, which results in <em>Agnimandya</em>. <em>Agnimandya</em> is corrected by <em>Samsarjana krama</em>. Thus, the successful administration of <em>Panchakarma</em> is solely dependent on the person's <em>Agni</em> status. So, in this paper, a humble attempt is made to understand the role of <em>Agni</em> in <em>Panchakarma</em> practice.</p> Haritha.K.S, P. Murali Krishna Copyright (c) 2023 International Journal of Ayurveda and Pharma Research Fri, 10 Nov 2023 00:00:00 +0800 Important Role of Herbal Extracts in the Management of Breast Cancer <p>Cancer recognized as a serious disorder among population worldwide. Breast cancer has been found common in women. Breast cancer diagnosed patients increasing with passage of time, which bringing the attention of researcher to give more potential strategies to irradiate this ailment from the society. Natural remedies from medicinal plants are well acknowledged from primitive time of decade. Modern and advanced analytical tools successfully overcome the burden of this disease by incorporating raw formulations into suitable dosage forms and their efficacy can be determined through experimental and clinical studies. There are numerous medicinal plants present having pharmacological potential to decreases the breast cancer cell viability by involving various mechanisms and significantly overcome the global burden of this disorder. Our presented study motivated from the burden of breast cancer among people and its treatment from natural sources. However, it is much needed to understand etiology of the disease and its associated causes. We also demonstrated the treatment strategies originated from natural sources that conquer the spectrum of this disorder. There are numerous types of natural products that has preventive and curative role in the management of breast cancer. So, accurate method and terminology required to elevating the demand of health care system from natural sources can overcome breast cancer.</p> Shiv Kumar, Avneet Gupta, Vinod Kumar Gauttam, Karan Sharma, Amar Deepak, Rohit Thakur Copyright (c) 2023 International Journal of Ayurveda and Pharma Research Fri, 10 Nov 2023 00:00:00 +0800 Some Specific Garbhavyapad Related with Placenta Previa and Fetal Growth Retardation in Modern Science <p>Ayurveda, one of the oldest systems of medicine, is momentous in audience of worldwide on virtue of its holistic approach of life. Ayurveda has its origin back to the <em>'Vedic</em>-era'. It has its mentioning in the <em>Atharva Veda</em>. Many historians claim that it is a part of <em>Atharva</em> <em>Veda</em> Ayurveda is also known as the <em>Upveda</em> of <em>Atharva Veda</em>. The Ayurveda term <em>Sharir Rachana </em>deals with anatomical and physiological consideration of the human body right from intrauterine life (before birth) till death. Ayurveda is one of the traditional sciences of pregnancy and foetal care management. The ancient anatomical knowledge like <em>Masanumasika garbha vridhi </em>and <em>Garbhaa vyapad</em> provides great understanding about the foetal growth and various structural and functional anomalies. The understanding of abnormalities is very important for the treatment of various diseases. According to Ayurvedic principles, pre-conception care is a set of interventions which are essential prerequisite for a healthy progeny. Maximum of Ayurvedic principles have proved true in today’s scientific research. Many of classical factors have accepted by modern medical science. Here in this article, a try has made to show the similarity between some of the <em>Garbha vyapad</em> described in ancient Ayurvedic texts and placenta previa and fetal growth retardation described in modern texts. The term <em>Garbha vyapad</em> refers to the calamity of the foetus. Under some conditions like too much fasting, eating stale food, not consuming fats as required, consumption of <em>Vata</em> vitiating objects in access, etc. leads to the foetus does remains in the uterus for a long time and doesn’t quiver.</p> Priyanka Kumari, Sanjiv Kumar, Shyam Sundar Gupta Copyright (c) 2023 International Journal of Ayurveda and Pharma Research Fri, 10 Nov 2023 00:00:00 +0800 A Clinical Study to Assess the Role of Vasantika Vamana on Lipid Profile and Weight in Healthy Individuals <p><em>Panchkarma</em> is the most integral part of Ayurvedic management. It is precautionary, promotive, conservative, therapeutic and reconstructive therapy. As per Ayurveda, the seasonal variations have an impact on the biological systems eliciting into the accumulation and aggravation of specific <em>Doshas </em>in a particular season like <em>Kapha</em> accumulation in <em>Hemanta Ritu</em> and aggravation in <em>Vasanta Ritu</em>, <em>Pitta </em>accumulation in <em>Varsha ritu</em> and aggravation in <em>Sharada ritu</em> and <em>Vata</em> accumulation in <em>Grishma Ritu</em> and aggravation in <em>Pravrita Ritu</em>. <em>Vasantika Vamana</em> is carried out approximately in the month of <em>Chaitra -Vaishakha </em>for the expulsion of vitiated <em>Kapha dosha</em> for forbidding the impending ailments like allergic bronchitis, allergic rhinitis, allergic sinusitis, bronchial asthma, migraine, psoriasis, indigestion, anorexia, lethargy, hyperacidity, dyslipidemia, diabetes mellitus, obesity, acne vulgaris, eczema, urticaria, etc. Total of 57 volunteers were registered in this study out of which 45 were coped with classical&nbsp;<em>Vamana Karma</em>. The study was accomplished on 45 evidently healthy volunteers, between the age group of 18 and 60 years to observe the changes in lipid profile and weight before and after <em>Vamana</em> procedure. The outcome of the study was significant.There was also an improvement in appetite (<em>Agni</em>) of the volunteers after <em>Vamana</em>. Volunteers with irregular bowel habits showed significant improvement. On an average the minimum, maximum, total dose and total days of <em>Snehapana</em> were 36.40ml, 187.21ml, 578.59ml and 5.01 days respectively. Average quantity of <em>Madanaphala, Ksheera, Yashtimadhu Phanta</em>&nbsp;and&nbsp;<em>Lavanodaka</em> was 5.81g, 1130.29ml, 3202.9ml and 2489.13 ml respectively.&nbsp;</p> Charu Supriya, Nidhee Thakur, Pooja Kaushik Copyright (c) 2023 International Journal of Ayurveda and Pharma Research Fri, 10 Nov 2023 00:00:00 +0800 A Comparative Evaluation and Understanding of the Taxonomical Characteristics, Pharmacological Attributes, and Therapeutical Potential of Tulasi (Ocimum sanctum Linn. Linn.) and Bhustrina (Hyptis sauveolans (Linn.) Poit.) <p>Usage of medicinal plants as a source for medicine has been the base of Ayurveda and has been in practice since the Vedic period. This has been a driving force for exponential growth and globalization of the science through ages into what we face in the current generation. Increased demand of a drug ultimately leads to over exploitation of the drug and brings forward the risk of shortage, abuse, and unavailability of the drug. The issue of unavailability of a drug has been prevailing since the 16<sup>th</sup> century AD and to overcome these issues, various classical literatures like <em>Yoga ratnakara</em> have stressed on the concept of<em> Abhava pratinidhi Dravya</em> or substitutes. With each passing day, newer and newer pharmaceutical products are being introduced into the market utilizing the available resources, hence the necessity of introducing and replacing endangered and risky medicinal plants have become inevitable to balance out the ecosystem<em>. Tulasi</em> (<em>Ocimum sanctum Linn.</em> Linn.) is an Ayurvedic drug used in clinical practice, pharmaceutical industries, and clinical applications for their diverse and potent pharmacological activities. Even though <em>Tulasi</em> naturally grows as a weed, excessive usage, Harsh climatic conditions, and demand for its antimicrobial activity has put <em>Tulasi</em> at risk for its availability. This study is focused on another drug <em>“Bhustrina”- Hyptis sauveolans Poit</em> which also belongs to <em>Lamiaceae</em> family and is a common weed. The study mainly emphasizes to evaluate and understand and compare the similarity in taxonomical characteristics, Pharmacological attributes, and therapeutical potential of <em>Tulasi</em> and <em>Bhustrina</em> and thereby include <em>Bhustrina</em> as a potential replacement for <em>Tulasi</em>.</p> Sethu. R Copyright (c) 2023 International Journal of Ayurveda and Pharma Research Fri, 10 Nov 2023 00:00:00 +0800 Pharmaceutical and Analytical Study on Aranaladi Taila <p><em>Rasashastra and Bhaishajya Kalpana </em>is the branch of Ayurveda which deals with the preparation of herbal (<em>Kashtoushadhis</em>), mineral (<em>Rasoushadhis)</em> and herbomineral preparations.<em> Bhaishajya Kalpana </em>is a specialized branch which deals with the identification, collection, processing compounding and dispensing of Ayurvedic formulations. It comprises various dosage forms.<em> Sneha Kalpana</em> is a variant of <em>Oushada Kalpana</em> in which <em>Sneha paka</em> is performed using prescribed <em>Kalka dravya</em> and <em>Drava dravya</em> It includes <em>Ghrita Kalpana</em> and <em>Taila Kalpana</em>, among them <em>Taila Kalpana</em> is an important dosage form widely used in Ayurvedic industry. <em>Aranaladi taila</em> is an effective oil preparation mentioned in <em>Sahasrayoga Taila prakarana,</em> which contains <em>Kanji, Tila taila</em> and <em>Sarjarasa.</em> The term <em>Aranala </em>represents <em>Kanji,</em> which is the fermented form of rice water. By this process absorption of therapeutic active principles of the ingredients are ensured. In this formulation <em>Kanji</em> is the <em>Dravadravya, Sarjarasa</em> is the <em>Kalka</em> and <em>Tilataila</em> is the <em>Sneha dravya</em>. <em>Aranaladi taila</em> is indicated in <em>Vatarakta</em> associated with <em>Jwara, Daha </em>and <em>Vedana. </em>In the present study, an attempt was made to validate the pharmaceutical preparation of <em>Aranaladi taila</em>. The current study included a detailed pharmaceutical process and physico-chemical evaluation of <em>Aranaladi taila.</em> The physicochemical parameters included are Refractive index- 1.474, Acid value- 4.4, Iodine value- 97.4, Saponification value- 179.5 and Loss on drying- 0.40%w/w. HPTLC analysis revealed the variable number of spots, however, due to the absence of a standard marker compound the chemical constituent could not be identified.</p> Neethu P, Rekhasree Pillai, Sanila V.K, Leena K.C Copyright (c) 2023 International Journal of Ayurveda and Pharma Research Fri, 10 Nov 2023 00:00:00 +0800