International Journal of Ayurveda and Pharma Research https://www.ijapr.in/index.php/ijapr <div align="justify"> <p class="para1"><strong>International Journal of Ayurveda and Pharma Research (IJAPR)</strong>&nbsp;is an international peer reviewed Monthly open access Online and Print journal. The aim of the journal is to increase the impact of research in both academic and industry, with strong emphasis on quality and originality. The journal promotes to publish the articles in the field of&nbsp;<strong>Ayurveda, Siddha, Yoga, Naturopathy, Unani, Homeopathy and Allopathy</strong>&nbsp;systems of medicine and Pharmaceutical Sciences. Researchers may submit (1). Original Research Articles (2). Review articles (3). Book Reviews (4). Short Communications/ Research Letter (5). Case Report (6). Letter to the Editor/Correspondence.</p> </div> International Journal of Ayurveda and Pharma Research en-US International Journal of Ayurveda and Pharma Research 2322-0902 Pharmacological Actions of Valeriana Wallichii (Tagara): A Fundamental Analysis Supporting Traditional Benefits https://www.ijapr.in/index.php/ijapr/article/view/2468 <p><em>Valeriana wallichii</em> referred to as <em>Indian Valeriana</em> has a family circle <em>Valerianaceae</em> commonly known as <em>"Tagara".</em> India, Nepal, and China are home to the important variety of the <em>Valeriana</em> genus. It is indigenous to India and can be found between 8000-10000 feet altitudes in the Himalayan region. <em>Valeriana</em> is a popular ethnobotanical remedy throughout Europe for relieving stress and improving sleep. Vital Central nervous system (CNS) activity is mirrored in the genuine Ayurvedic text-based content and declared as<strong>&nbsp;</strong>one of the&nbsp;handiest&nbsp;treatments&nbsp;with inside the&nbsp;remedy&nbsp;of neurosis and is&nbsp;powerful&nbsp;in pacifying the&nbsp;body ache&nbsp;(<em>Vedanasathpana</em>), chills (<em>Sheetprashmana</em>), and headaches (<em>Shirah shoolprshmana</em>). Additionally, it has been addressed in the <em>Charaka Samhita </em>as a remedy for snake poisoning. The rhizome and supporting tissues of valerian are used to treat insomnia, epilepsy, hypertension, and psychosomatic disorders. Important phytochemicals can reduce pain, manage stress, protect the brain from radiation, and fight off microbes. Hesperidin, the statutory potent flavonoid, 6-methylapigenin, and four new varieties of the iridoids Valeriotetrates B and C, 8-methylvalepotriate, and 1,5-dihydroxy-3,8-epoxyvalechlorine A are just a few of the naturally occurring active phytochemicals in the <em>Valeriana wallichii</em>.</p> Tripti Tyagi Sakshi Sharma Rajesh Sharma Copyright (c) 2022 International Journal of Ayurveda and Pharma Research https://creativecommons.org/licenses/by-nc-sa/4.0 2022-09-10 2022-09-10 1 7 10.47070/ijapr.v10iSuppl1.2468 Kandughna Gana Varti in Vulvo Vaginalcandidiasis - A Case Series https://www.ijapr.in/index.php/ijapr/article/view/2475 <p>Vulvovaginal candidiasis is an infection caused by yeast like micro organisms called candida albicans. It is the second most common cause of vaginitis affecting women of reproductive age group. It is most distressing and irritating to women, hampers their day to day life and makes them irritable, depressed, anxious and disturbs their interpersonal relationships including marital life. In vulvovaginal candidiasis patients complain of vaginal discharge with intense vulvovaginal pruritus. The pruritus is out of proportion to the discharge. The symptoms of vulvovaginal candidiasis appear similar to the symptoms of <em>Slaishmiki yoni vyapath</em> mentioned in Ayurvedic classics. It is due to the vitiation of <em>Kapha</em> caused by usage of <em>Abishyandi aharas</em> and has symptoms like <em>Pichila yonisrava, Kandu, Alpa vedhana</em> or <em>Avedhana</em> in <em>Yoni</em>. Topical treatments have great importance in the treatment of several gynecological conditions (<em>Yoni vyapaths</em>). <em>Yoni varti</em> or vaginal pessary is used to cleanse the vaginal walls and make the local environment more healthy. It acts directly on the vaginal mucosa and enables easier and target specific action. They are also hygroscopic in property and act in accordance with the drugs they contain. <em>Kandughna</em> <em>gana varti </em>have<em> Tiktha, Kashaya rasa, Laghu, Ruksha guna, Krimighna, Kandughna </em>and<em> Kaphaghna </em>properties and all the ingredients have potent antifungal action also. This facilitates faster absorption of drugs through vaginal mucosa and relieves the symptoms more quickly. A pilot study was conducted in 5 cases to assess the effect of <em>Kandughna gana</em> <em>varti</em> in vulvovaginal candidiasis. It was found to be effective in vaginal discharge and vulvovaginal pruritus.</p> Simi Raj K K Maya Balakrishnan Giby Thomas Copyright (c) 2022 International Journal of Ayurveda and Pharma Research https://creativecommons.org/licenses/by-nc-sa/4.0 2022-09-10 2022-09-10 8 12 10.47070/ijapr.v10iSuppl1.2475 Vayasthapana Gana Ksheerapaka in Perimenopausal Symptoms - A Case Report https://www.ijapr.in/index.php/ijapr/article/view/2476 <p>Perimenopause is the transition period from reproductive to non-reproductive phase. It usually begins with menstrual cycle irregularity and extends to one year after permanent cessation of menstruation. There is manifestation of varied physical, psychological and somatic symptoms. Menopause may be correlated to <em>Rajakshaya.</em> It usually occurs as part of the ageing process and is the period of transition from <em>Pitta</em> predominant middle age to <em>vata </em>predominant old age. Treatment in modern medicine includes hormone replacement therapy and use of anti-depressants etc. Acharyas mention <em>Jara</em> among <em>Swabhavabala pravritta Vyadhi</em>, and its management is to be done with drugs having <em>Rasayana</em> property. Here we present a 48-year-old lady who presented with complaints of hot flushes, severe sweating especially during night hours, reduced sleep, irritability, multiple joint pain, loss of interest in most daily activities and stress incontinence. <em>Vayasthapana gana</em> was administered as <em>Ksheerapaka. Vayasthapana gana </em>include ten drugs which are<em> Rasayana, Medhya, Tridosha samana</em> and possess anti-oxidant, free radical scavenging and anti-stress activity. <em>Ksheera</em> is <em>Vata pitta samana, Rasayana, </em>and<em> Jeevaneeya</em>. <em>Vayasthapana gana ksheerapaka</em> is given in the dose of 48ml twice daily one hour before food for thirty days. After treatment intensity of these symptoms were reduced. Follow up was done thirty days after stopping the medication, here also intensity of these symptoms remained less when compared to before treatment. Here we reviewed the probable role of <em>Vayasthapana gana ksheerapaka</em> in alleviating perimenopausal symptoms.</p> Aswathi Ullas Maya Balakrishnan Jyothi P K Copyright (c) 2022 International Journal of Ayurveda and Pharma Research https://creativecommons.org/licenses/by-nc-sa/4.0 2022-09-10 2022-09-10 13 16 10.47070/ijapr.v10iSuppl1.2476 Ayurvedic Management of Tamaka Swasa w.s.r to Bronchial Asthma https://www.ijapr.in/index.php/ijapr/article/view/2495 <p>Bronchial asthma is one of the most distressing chronic illness in all socio- economic status people, affecting all age groups. Changing in lifestyle, demographic factors, urbanization, environmental charges are the triggering factors of bronchial asthma. <em>Tamaka</em> <em>swasa</em> is characterized by paraoxysmal attacks of breathlessness, cough, coryza, due to chest tightness, rapid respiration, distress inability to expectorate and prolonged expiration. <strong>Methods: </strong>This is a single case study of a 34 year male patient, came with the complaints of difficulty in Breathing since 5 years. He also complaints of abdominal distension and decreased appetite. According to patient, he was apparently well before 5 years. Gradually he developed breathing difficulty because of his smoking habit. Patient also c/o abdominal distension and decreased appetite at that time. In the case study patient was given <em>Sadhyo</em> <em>vaman</em> first followed by <em>Snehapana</em> with <em>Brahmi</em> <em>ghrta</em> was given along with Internal medications. <strong>Result: </strong>Patient showed remarkable improvement in severity of symptoms and as well as time period between 2 successive episodes of dyspnea is increased. During this course we observed that the patient had partial relief of symptoms. Lesser the chronicity greater the relief and improvement in chronic condition was observed. <strong>Interpretations and Conclusion</strong>: The patient was given <em>Sadhyovamana</em>, followed by <em>Snehapana</em> with <em>Brahmi</em> <em>ghrtam</em> for <em>Virechana</em>. The contents of <em>Brahmi</em> <em>ghrtham</em> are Ghee, <em>Brahmi</em>, <em>Shankapushpi</em>, <em>Trikatu</em>, <em>Shweta</em> <em>trivrt</em>, <em>Krishna Trivrt, Vidanga, Nipadruma, Saptala, Danti,</em> followed by <em>Virechana</em> with <em>Trivrt</em> <em>lehaya</em>. <em>Tamake tu virechana </em>In this condition <em>Virechana </em>is advised as the best line of treatment, and in the above mentioned case after <em>Virechana </em>patient feels better and got much more relief from symptoms.</p> Kalaivanan. J Soumya E.A Copyright (c) 2022 International Journal of Ayurveda and Pharma Research https://creativecommons.org/licenses/by-nc-sa/4.0 2022-09-10 2022-09-10 17 20 10.47070/ijapr.v10iSuppl1.2495 Ayurvedic Management of Emesis Gravidarum - A Case Report https://www.ijapr.in/index.php/ijapr/article/view/2500 <p>Emesis is a common experience in first trimester of pregnancy affecting 70 to 80% of all pregnant women. Altered immunological endocrinological and psychological states are responsible for initiation of symptoms. Mild to moderate emesis gravidarum have a significant adverse effect on quality of women's life. Even though onset is physiological its morbidity has to be reduced to minimize disease burden, enhance maternal health and to prevent hyper emesis gravidarum. Anti-emetic and anti-histamines are used in conventional Allopathic practice. Ayurvedic principle is early intervention and prevention of hyperemesis gravidarum with lifestyle modifications and adopting <em>Pathya ahara. </em>This is a case report of emesis gravidarum managed with pharmaco nutrient product –<em>Malarinji modaka</em></p> Shahina Mole S Deepa C R Copyright (c) 2022 International Journal of Ayurveda and Pharma Research https://creativecommons.org/licenses/by-nc-sa/4.0 2022-09-10 2022-09-10 21 23 10.47070/ijapr.v10iSuppl1.2500 Conceptual and Literary Analysis on Bhurjah (Betula Utilis D. Don) https://www.ijapr.in/index.php/ijapr/article/view/2452 <p><strong>Aim</strong>- To review comprehensive literature on <em>Bhurjah (Betula utilis</em> D. Don) w.s.r. to its therapeutic activity. <strong>Background</strong>- <em>Bhurjah</em> <em>(Betula utilis </em>D. Don) is a very ancient traditional medicine, commonly known as <em>Bhojpatra</em> in Hindi and Himalayan birch in English. Bark of <em>Betula utilis </em>was used in ancient times for writing Sanskrit literature and texts. Ancient sages used <em>Bhojpatra </em>to write down manuscripts and those literature remains unaffected by microbes, environmental and biological factors. From immemorial time <em>Bhurjah</em> has been used in <em>Yagya karma </em>by the sages. <strong>Material And Methods</strong>- The literature review was compiled from distinctive available Ayurvedic literatures and various published literature relevant to <em>Bhurjah.</em> <strong>Conclusion-</strong> <em>Bhurjah</em> widely used in Ayurvedic system of medicine in the treatment of various diseases like <em>Kustha</em> (various skin diseases), <em>Karnashoola </em>(otalgia), <em>Visarpa </em>(erysipelas), <em>Medovishahara </em>(anti-obesity and anti-toxic), <em>Vranashodhana </em>(wound purification) and <em>Tridoshashamana</em> (<em>Vata, Pitta, Kapha </em>alleviation). It has studied for various therapeutic activities like, anti-microbial activity, anti-oxidant activity, anti-inflammatory activity, mild anti hyperglycemic activity, anticancer activity, anti-HIV activity. An effort has been done to explore the evidence based pharmacological activities of <em>Bhurjah</em>.</p> Monika Kunwar Shalini Varshney Yogita Munjal Copyright (c) 2022 International Journal of Ayurveda and Pharma Research https://creativecommons.org/licenses/by-nc-sa/4.0 2022-09-10 2022-09-10 24 31 10.47070/ijapr.v10iSuppl1.2452 Conceptual Study of Ama and its Manifestation in Various Diseases https://www.ijapr.in/index.php/ijapr/article/view/2496 <p>Like the theories of <em>Tridosha, Sapta Dhatu</em>, and <em>Trimalas,</em> the concept of <em>Agni </em>and <em>Ama </em>are very unique conceived in Ayurvedic texts. The concept of <em>Ama</em> encompasses an almost whole spectrum of diseases mentioned in Ayurveda. In the Ayurvedic view, nearly all diseases have their origin in <em>Ama dosha.</em> In Ayurveda, the word <em>Ama</em> and <em>Pakva </em>are very important to understand the theories of pathology and treatment according to Ayurveda. The success or failure of the Ayurvedic Physician in treatment depends upon the understanding of two conditions, <em>Sama</em> and <em>Nirama</em>- immature and mature. In <em>Ama dosha langhan</em> or fasting is the general form of treatment. Even medicine is forbidden in acute conditions. As the <em>Jathragni</em> is already weak and struggling to digest <em>Ama,</em> it can’t digest the medicine, another newcomer. The interaction of <em>Doshas</em>, food, and medicine may cause even fatal results.</p> Gahalawat Manpreet Gahalawat Preeti Kumar Krishan Copyright (c) 2022 International Journal of Ayurveda and Pharma Research https://creativecommons.org/licenses/by-nc-sa/4.0 2022-09-10 2022-09-10 32 36 10.47070/ijapr.v10iSuppl1.2496 Geriatric Depression in India; Causes and Solutions: An Ayurveda Perspective https://www.ijapr.in/index.php/ijapr/article/view/2472 <p>Geriatric Depression (GD) prevalence rate is on the rise as is the geriatric population in India. It can be correlated to <em>Kaphaja Unmada</em> in Ayurveda based on its causes and symptoms. GD patients have symptoms like <em>Mandavakchesta</em> (slowing of speech and actions), <em>Tushnibhava</em> (depressed look), <em>Anaannabhilasha </em>(disinclination for food)<em>. </em>GD has several causative factors like decreased physical agility, cognitive decline, lack of financial liberty, social isolation, long standing diseases and medicines etc. Following the surge of industrialization, urbanization like western countries after 1980s, the family systems and values in India have changed. Nuclear families are on rise and elderlies in families are considered as burden. Contrastingly, earlier elderlies were regarded as source of wisdom and guidance. This study is an attempt to go through all the possible literature offline and online to find out the causes and solutions of GD in India. Findings showed that along with the common causative factors related to the old age in elderlies, ignorance from younger family members is also equally important. GD is a psychosomatic disease, so treatments approach involving the body, mind, family dynamics and values using family psychotherapies and psychoeducation, <em>Medhya rasayana </em>and if needed modern psychiatric medication can address all types of GD and related mental health problems in India.</p> Prashant Banet Vijayendra Bhat G Aniruddha Saralaya Copyright (c) 2022 International Journal of Ayurveda and Pharma Research https://creativecommons.org/licenses/by-nc-sa/4.0 2022-09-10 2022-09-10 37 44 10.47070/ijapr.v10iSuppl1.2472 Soul Seat- Realization of Spiritual Being https://www.ijapr.in/index.php/ijapr/article/view/2499 <p>We are spiritual beings with human experience, but how can we realize that we are spiritual beings is a tedious task for which the whole world is trying for ages. Spiritual world starts from <em>Kundalini</em>, <em>Chakras</em>, 5 <em>Tatva</em> etc origin of all connects us with our spiritual self but it's very complicated and needs lot of hand holding from an enlightened <em>Guru</em>. We have created a structure where a simple analogy when connected to few breathing exercises and touching the point again and again with <em>Beejmantra</em> invokes the spiritual being inside. Thus the spiritual being outside the body can be identified and thus can be connected. While studying neuroscience several micro networks were observed in the human body by scientists, human health has deep connection with immunity, inner peace, justice and happiness. Behavior has become increasingly prominent in psychological theory of biological models, especially in neuro-imaging tools development. Thus one can realize that every particle bears intelligence and there is a cumulative intelligence which governs the course of action of one single particle, creator of Intelligence is the spiritual being who created the cosmos. This thought when applied time and again connected everyone on a divine knowledge path where everything starts connecting and the person becomes a master of all traits. Connecting soul seat increased conversion of air, fire &amp; water to <em>Pran</em>, <em>Tej</em> &amp; <em>Oaj</em> and reduced <em>Vaat</em>, <em>Pitta</em> &amp; <em>Kapha</em> thus <em>Bala</em> increased and body attained strong immunity against diseases and longevity. Resistance against disease increased on physical, mental, emotional &amp; spiritual level. Thus connecting with soul seat, its understanding and how and where it influences the society is the scope of the study. &nbsp;</p> Arti Shukla Gaurav Shukla Copyright (c) 2022 International Journal of Ayurveda and Pharma Research https://creativecommons.org/licenses/by-nc-sa/4.0 2022-09-10 2022-09-10 45 53 10.47070/ijapr.v10iSuppl1.2499 Scientific Understanding of Cytokine Storm in Perspective of Ayurveda: A Review https://www.ijapr.in/index.php/ijapr/article/view/2497 <p>Cytokine storm also known as cytokine releasing syndrome is due to elevate level of circulating cytokine and hyper action that can be triggered by some factor like virus, bacteria or other epigenetic factors. In this era of communicable disease, COVID-19 is such a disease which shows manifestation in the form of cytokine storm. Increase level of cytokine like interleukin-6 etc in the blood causes destruction of normally functioning cell leads to dangerous life-threatening condition like ARDs. Cytokines are immunomodulating agents composed of soluble proteins, peptides and glycoproteins secreted by haemopoietic and non-haemopoietic cells in response to various stimuli. Their main role is in molecular interaction between various cells of the immune system. Cytokines are nothing but just the immune markers which hyperactivation leads to cytokine storm. There is not any description of such pathogenesis in Ayurveda. But Ayurveda clearly defined some concepts of immunity such <em>Asvyadhikshamatva, Oja, Bala, Vyadhibighatakarabhaba</em> and <em>Rasayana</em>. In Covid-19, researcher found that such people are more vulnerable to disease and its severity. Such vulnerability depends upon person response to illness. Ayurveda may explain this vulnerability through its concepts of preventive, personalized and rejuvenation. The present review focused on cytokine storm and its understanding in perspective of Ayurvedic concepts of immunity</p> Lilishree Meher Ankur Kumar Tanwar Mahesh Vyas Copyright (c) 2022 International Journal of Ayurveda and Pharma Research https://creativecommons.org/licenses/by-nc-sa/4.0 2022-09-10 2022-09-10 54 57 10.47070/ijapr.v10iSuppl1.2497 Human Body and its Relation with Planets Siddha Perspective https://www.ijapr.in/index.php/ijapr/article/view/2454 <p>Siddha system is the foremost traditional system, which was introduced by ancient Siddhar’s. According to Siddhar’s, nature is man, man is nature. Man is said to be microcosm and universe is macrocosm. The universe is made up of five elements namely Earth, Water, Fire, Air, and Space. Our body is also made up of five elements <em>(Panchaboothas</em>), three vital humors known as <em>Vatham</em> (air, space), <em>Pitham </em>(fire), <em>Kabam</em> (Earth, water), seven physical constituents are <em>Saram </em>(nourishing fluid), <em>Senneer</em> (blood), <em>Oonn</em> (muscles), <em>Kozhuppu</em> (adipose tissue), <em>Enbu </em>(bone), <em>Moola</em>i (bone marrow), <em>Sukkilam/Suronitham</em> (sperm/ovum) respectively. The universe has stars and planets. Each planet has an influence that reflects in our bodies. Thoughts were controlled by cosmic force in the universe. Nine planets in the universe correlate with the organs in the body Sun-Heart, Moon-Brain, Mercury-Lungs, Jupiter-Liver, Saturn-Spleen, Mars-Gall Bladder. This article explains how the planets have a connection with our human body.</p> Arthi.G Lakshmanakumar.V Rathinam.J Sushil Kumar P N Copyright (c) 2022 International Journal of Ayurveda and Pharma Research https://creativecommons.org/licenses/by-nc-sa/4.0 2022-09-10 2022-09-10 58 62 10.47070/ijapr.v10iSuppl1.2454 Significance of Siddha Thirithoda Balancing Food Stuffs https://www.ijapr.in/index.php/ijapr/article/view/2455 <p>The Siddha system of medicine is an ancient medical system, which provides ‘Holistic Health’. The word ‘<em>Siddha</em>’ originated from the&nbsp; word <em>‘Siddhi’</em> meaning achievement of perfection, eternal bliss and accomplishment. The Siddha system evolved based on ninety-six tools (96 Thattuvam) which include physical, physiological, psychological and intellectual aspects of every human being. Among the 96 tools, the five elements i.e. Pancha bootham namely Earth, Water, Fire, Air and Space are the fundamental units of everything in the human body and the cosmos. There are three vital life factors (Vaatham, Pittam, Kabham) responsible for good health. There is a relationship between these to maintain the body’s healthy. Any increase or decrease in humour causes diseases. Thirthoda sama porutkal (TSP) maintains these humour when we are using our regular diet. This article details the TSP to maintain the body healthy.&nbsp;</p> Sushil Kumar P N Arthi G Rathinam.J Geetha A Lakshmanakumar V Aishwarya A Mirunaleni P Monika T Chaitanya Krithika G Akila B Copyright (c) 2022 International Journal of Ayurveda and Pharma Research https://creativecommons.org/licenses/by-nc-sa/4.0 2022-09-10 2022-09-10 63 68 10.47070/ijapr.v10iSuppl1.2455